Carbon monoxide transfer coefficient KCO (TL/VA): a flawed index L
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منابع مشابه
Carbon monoxide transfer coefficient KCO (TL/VA): a flawed index.
In their recent "Perspective", HUGHES and PRIDE [1] described the carbon monoxide (CO) transfer factor (TL,CO) as the product of two primary measurements: alveolar volume (VA) and CO transfer coefficient KCO (TL/ VA). VA is primary in that it has a physiological identity. However, FORSTER [2] has pointed out that in the context of the measurement of transfer factor, the volume is merely that of...
متن کاملInterpretation of increases in the transfer coefficient for carbon monoxide (TLCO/VA or KCO).
During a 15-month period, 27 patients were seen in a routine clinical pulmonary function laboratory in whom the transfer coefficient (TLCO/VA or KCO), measured by the single breath technique, was increased. Pulmonary haemorrhage accounted for two-thirds of the cases; in them sequential measurements of KCO were able to monitor the onset and cessation of bleeding. In the remaining cases the cause...
متن کاملIn defence of the carbon monoxide transfer coefficient Kco (TL/VA).
The carbon monoxide transfer factor (TL,co) is the product of the two primary measurements during breath-holding, the CO transfer coefficient (Kco) and the alveolar volume (VA). Kco is essentially the rate constant for alveolar CO uptake (Krogh's kco), and in healthy subjects, increases when VA is reduced by submaximal inflation, or when pulmonary blood flow increases. Recently, new reference v...
متن کاملCarbon monoxide transfer coefficient (transfer factor/alveolar volume) in females versus males.
The single breath transfer factor of the lung for carbon monoxide (TL,CO) is derived from the multiple of the carbon monoxide transfer coefficient (KCO) and the alveolar volume (VA) during breath holding [1]; consequently, the TL,CO is highly dependent on lung size (yVA), and thus is smaller in females for a given height and age. Essentially, the KCO is the rate constant for alveolar carbon mon...
متن کاملThe alveolar carbon monoxide uptake fraction: a simple, alternative measure of carbon monoxide transfer.
The measurement and interpretation of "diffusing capacity" by either single-breath or steady-state methods are complicated by both technical and conceptual difficulties. The CO uptake fraction is less complex but, as originally described, it is unacceptably sensitive to dead-space ventilation. A modification (the "alveolar CO uptake fraction", UA) largely removes this factor. We have measured U...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2001
ISSN: 0000-0000,0903-1936
DOI: 10.1183/09031936.01.00246701